No.9（2014）7.A simple fabrication of wound dressings with suppressed release of antibacterial agents using electrostatic properties of poly(vinyl alcohol)

Shunji Yunoki, Masushi Kohta, Yoshimi Ohyabu, Masayuki Sekiguchi, Takabumi Kubo, Tetsuji Iwasaki

  Hydrogel wound dressings with suppressed release of antibacterial agents are fabricated by chemical reactions or syntheses for attaching or incorporating antibacterial moieties into polymer backbones. However, such polymeric systems often fail to satisfy one of the basic requirements for wound dressings, such as easy and inexpensive synthesis. It is speculated that a positively charged organic antibacterial agent is attracted to polar groups of polyvinyl alcohol (PVA) hydrogels and shows suppressed release. PVA hydrogels containing cetylpyridinium chloride (CPC) are prepared by gamma irradiation. CPC is barely released from the hydrogels, probably due to electrostatic interactions, and is stable upon gamma irradiation. The suppressed release of CPC confers antibacterial activity against Escherichia coli on the surface of hydrogels, while no inhibition zone is observed around the hydrogels. CPC-containing PVA hydrogels are easy to prepare and contain known and safe materials. The simplicity and safety of the procedure for achieving suppressed release of antibacterial agents are advantages of CPC-containing PVA hydrogels.

Keywords
Keywords：Adsorption, Biomedical applications, Hydrogel, Wound dressing, Gamma crosslinking

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