本文
No.3（2008）7.Formation of Ca-P-O Coating on Titanium Substrate by High Energy Ion Irradiation and Sputter Deposition
Shohei Taniguchi, Masayuki Sekiguchi, Yasuhito Kinjo, Noriyuki Miyazaki, Elito Kazawa
Ca-P-O coating was formed on pure Ti substrates by sputter deposition. After coating the substrates were irradiated with silicon ions using a high energy (3MeV) ion accelerator. The characterization of coated substrates was examined by a scratch tester, scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS) and transmission electron microscopy (TEM). Compatibility of substrates with bone tissue was examined using the mouse osteoblast cell line MC3T3-E1. The results of the analyses (SEM, XPS and TEM) indicated that the microstructure of sputter deposition coating is amorphous of Ca, P, O and metals. On the other hand, nano-particles were formed in the ion-irradiated coating on Ti substrates. It was found that the scratch strength of coating was increased by ion irradiation. The results of MC3T3-E1 cell growth suggested that biocompatibility can be maintained after coating by sputter deposition and ion irradiation. One side of the substrate was treated with coating and ion irradiation, and this was implanted into rat tibia. Two and three weeks after implantation, larger new bone formation on the treated side was observed compared with that on the untreated side. The results indicated that treatment by high energy ion irradiation after Ca-P-O coating is superior for early bone formation on Ti substrate.
Keywords
ion-irradiation, Ca-P-O coating, biocompatibility
